Wyatt was born March 10, 1982, in Indianapolis, Indiana, to Lorna Wyatt (a vocalist) and Keever Wyatt II (an organist and also a vocalist). Ke'Tara "Keke" Wyatt was raised in a musical family rooted in gospel music. She has four brothers. Despite her religious background, Wyatt was also exposed to Contemporary R&B and secular music, and she would perform with her vocals in genres as diverse as gospel, pop and opera. Wyatt began singing at the age of 2, experiencing her first live show by the age of 5. While of mixed white and black heritage, Wyatt and her four brothers, who were raised in a predominantly African-American household and community setting, identify as African-American. In addition to her parents' and maternal grandparents' interracial marriages, Wyatt's paternal grandmother is part Cherokee. Wyatt grew up in Indianapolis, but also spent time in both Kentucky and Texas. She attended high school in Indianapolis, where she was a member of her high school's varsity wrestling team. As she grew, her musical tastes were influenced by the likes of R&B greats like Stevie Wonder, Donny Hathaway and Ella Fitzgerald. Inspired by many preceding musical greats, Wyatt found herself performing with various girl groups as a teen. She was often recognized for a maturity exceeding her teenage years.