Durance rose to prominence in 2004, after being cast as Lois Lane on the popular television series Smallville, playing a sassy, street-smart teenage Lois in season four. Executive Producer Kelly Souders recalled hiring Durance stating: "There were a lot of wonderful actresses who came in for the role, but I remember sitting and watching her tape and everybody was like, 'That’s her. There's no question. '" Fellow producer Brian Peterson added that from the moment Durance was hired they knew she would be Lois for the series. Durance was promoted to series regular in season five and became part of the regular cast for the remainder of the series run. On playing Lois Lane Durance said: "Everyone has their specific idea of who Lois Lane is for them, and you have your overall blueprint, but then you have to try to make it your own. That's the only way to try to stay truthful to what you're doing. It's an experience I will cherish always and never forget. Lois is a beloved character. I took that seriously and put my heart and soul into her for seven years. I enjoyed every minute and am forever changed by it. "